I've lost friends to drunk drivers, and drinking is legal. Drink driving isn't, but it doesn't stop people from doing it, the freaking eejits.
I feel that drugs SHOULD be legalised. We'll never ever win the war on drugs. You can't win a war on a concept or on something like that. Legalisation allows taxation and control. Legalisation of drugs like marijuana allows for a lot more simplicity in medical use, in hemp production (a great sustainable product if ever there was one, so much better than cotton!) etc. It also allows enforcement regulations to change. So that the money we're pouring into stupid ad campaigns now to be put into education about the drugs.
Harder drugs, well... I'm not a massive fan, and that's due to life experience. But a lot of the issues with the harder drugs are the uncontrolled additives people put in. Yes, so many of them do NOT GOOD things to your system. Heroin is way out, coke is pretty out too for me. But it's the shit they put in E and cut things like coke with that's filler that causes a lot of the very adverse reactions.
Legalise it, tax it, and legislate it.