No one will beat Nolan Ryan's record. Ever. For many years pitcher's innings have gotten less and less. A complete game is getting more and more rare now and it is only getting less. The relief game and closer game is more common now and it wouldn't shock me in the future to see the average starter only going 5 or 6 innings tops before turning it over to the bullpen. Johan Santana is the perfect example as he is still fairly early in his career and there is no way he could throw 225 more strikeouts per year for another 20 years (he'd be forty-eight) to break Ryan's record. That record will stand forever.