Preacher, Transmetropolitan, Lucifer, Invisibles, Starman, Promethea, Sandman, soon to be Planetary, Y the Last Man, and 100 Bullets.
Notice that only one of these titles was considered a "mainstream Superhero" title. (THough Starman was anything but). Are creators just not given enough freedom on "universe" books to create something truly great? Most of the good superhero stories are either fringe or elseworld-type books.