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View Full Version : DARPA is working something you snort so that you dont need sleep...



Jason California
12-28-2007, 11:33 AM
I will finally be able to swear of my cocaine and amphetamine habit.
http://www.wired.com/science/discoveries/news/2007/12/sleep_deprivation


In what sounds like a dream for millions of tired coffee drinkers, Darpa-funded scientists might have found a drug that will eliminate sleepiness.

A nasal spray containing a naturally occurring brain hormone called orexin A reversed the effects of sleep deprivation in monkeys, allowing them to perform like well-rested monkeys on cognitive tests. The discovery's first application will probably be in treatment of the severe sleep disorder narcolepsy.

The treatment is "a totally new route for increasing arousal, and the new study shows it to be relatively benign," said Jerome Siegel, a professor of psychiatry at UCLA and a co-author of the paper. "It reduces sleepiness without causing edginess."

Orexin A is a promising candidate to become a "sleep replacement" drug. For decades, stimulants have been used to combat sleepiness, but they can be addictive and often have side effects, including raising blood pressure or causing mood swings. The military, for example, administers amphetamines to pilots flying long distances, and has funded research into new drugs like the stimulant modafinil (.pdf) and orexin A in an effort to help troops stay awake with the fewest side effects.

The monkeys were deprived of sleep for 30 to 36 hours and then given either orexin A or a saline placebo before taking standard cognitive tests. The monkeys given orexin A in a nasal spray scored about the same as alert monkeys, while the saline-control group was severely impaired.

The study, published in the Dec. 26 edition of The Journal of Neuroscience, found orexin A not only restored monkeys' cognitive abilities but made their brains look "awake" in PET scans.

Siegel said that orexin A is unique in that it only had an impact on sleepy monkeys, not alert ones, and that it is "specific in reversing the effects of sleepiness" without other impacts on the brain.

Such a product could be widely desired by the more than 70 percent of Americans who the National Sleep Foundation estimates get less than the generally recommended eight hours of sleep per night (.pdf).

The research follows the discovery by Siegel that the absence of orexin A appears to cause narcolepsy. That finding pointed to a major role for the peptide's absence in causing sleepiness. It stood to reason that if the deficit of orexin A makes people sleepy, adding it back into the brain would reduce the effects, said Siegel.

"What we've been doing so far is increasing arousal without dealing with the underlying problem," he said. "If the underlying deficit is a loss of orexin, and it clearly is, then the best treatment would be orexin."

Dr. Michael Twery, director of the National Center on Sleep Disorders Research, said that while research into drugs for sleepiness is "very interesting," he cautioned that the long-term consequences of not sleeping were not well-known.

Both Twery and Siegel noted that it is unclear whether or not treating the brain chemistry behind sleepiness would alleviate the other problems associated with sleep deprivation.

"New research indicates that not getting enough sleep is associated with increased risk of cardiovascular disease and metabolic disorders," said Twery.

Still, Siegel said that Americans already recognize that sleepiness is a problem and have long treated it with a variety of stimulants.

"We have to realize that we are already living in a society where we are already self-medicating with caffeine," he said.

He also said that modafinil, which is marketed as Provigil by Cephalon and Alertec in Canada, has become widely used by healthy individuals for managing sleepiness.

"We have these other precedents, and it's not clear that you can't use orexin A temporarily to reduce sleep," said Siegel. "On the other hand, you'd have to be a fool to advocate taking this and reducing sleep as much as possible."

Sleep advocates probably won't have to worry about orexin A reaching drugstore shelves for many years. Any commercial treatment using the substance would need approval from the Food and Drug Administration, which can take more than a decade.

Akira
12-28-2007, 11:35 AM
That's all well and good, but how does it interact with FOXDIE?

Ashwin Pande
12-28-2007, 11:37 AM
Ehh.. as much as I hate time wasted in sleeping.. the dreams usually form the basis for a lot of my creative ideas.

Pass.

JHickman
12-28-2007, 11:50 AM
If this ever does come about (i.e. getting by the FDA), it is going to be abused like crazy...

...and probably by me. :no:

TheKraken
12-28-2007, 12:49 PM
Oh man oh man. I only get any kind of restful sleep on the weekends. I simply can't adjust to the 8-5 world no matter how many years I've been a part of it. I feel like shit all the time... I would get hooked on this stuff immediately...

greg donovan
12-28-2007, 01:23 PM
i seriously doubt that narcoleptics will be the first humans using this drug.

DARPA=Military

soldiers will be using this stuff first.

Amos Moses
12-28-2007, 01:24 PM
i seriously doubt that narcoleptics will be the first humans using this drug.

DARPA=Military

soldiers will be using this stuff first.

Special Forces that never need to sleep. That's pretty scary.

Oh wait, I'm in America, that's AWESOME!

Jason California
12-28-2007, 01:36 PM
Special Forces that never need to sleep. That's pretty scary.

Oh wait, I'm in America, that's AWESOME!

Step 1 to our very own Universal Soldier !

greg donovan
12-28-2007, 01:37 PM
Step 1 to our very own Universal Soldier !

but will they still wanna be "like Mike?"

PimpSlapStick!
12-28-2007, 01:44 PM
Just what I need!

Now I can watch porn and be on the Bendo every waking moment. Yay

Jason California
12-28-2007, 01:51 PM
but will they still wanna be "like Mike?"

One can only hope.

PimpSlapStick!
12-28-2007, 01:57 PM
i seriously doubt that narcoleptics will be the first humans using this drug.

DARPA=Military

soldiers will be using this stuff first.

They'll definately test it on them.

Pia Guerra
12-28-2007, 02:03 PM
So instead of pilots wired on amphetamines blowing up wedding parties in the desert we'll just have them fall out of the sky and crash on said families when their hearts give out.

Uh huh.

I fear for the future.

Thomas Mauer
12-28-2007, 02:49 PM
So instead of pilots wired on amphetamines blowing up wedding parties in the desert we'll just have them fall out of the sky and crash on said families when their hearts give out.

Uh huh.

I fear for the future.

Ding ding ding!

Greenville 90210
12-28-2007, 03:11 PM
This can't possibly go wrong!

ZombieSpeedball
12-28-2007, 03:13 PM
And if you take too much, get ready to bleed out the eyes.

jess
12-28-2007, 03:15 PM
This can't possibly go wrong!

my thoughts exactly. there was a time when straight meth was the cure for all that could possibly ail ya. but i trust the fda. they'd never put out anything unsafe. :mistrust:

Whip
12-28-2007, 04:33 PM
Something you snort that keeps you up all night?

Cocaine.


Darpa fails.

Patrick King
12-29-2007, 06:10 PM
That's all well and good, but how does it interact with FOXDIE?
:thumb:

That's the first thing I thought of when I saw DARPA in the title.

The Human Target
12-29-2007, 06:13 PM
I have a feeling the Boogie Man is going to be pissed about this.